The Define S2 features a simple and clean design, and it's made from black metal, plastic and a little bit of aluminum. The front part is without any openings or slots, so you won't be able to install any 5.25" drives, card readers or fan controllers. The top comes with anI/O panel that features one USB 3.1 Gen2 Type-C port, two USB3.0 ports, two USB 2.0 headers and audio connectors. Last but not least you will find the power button as well.
On both sides the front features openings, which allow the front fans to pull in fresh air. The side panels are quite simple but Fractal Design has made a little change regarding the tempered glass integration. While most of the cases come with a tempered glass panel which is screwed to the main chassis, Fractal Design has created a glass panel that is attached like a regular steel side panel. The tempered glass panel has been glued to a slim steel frame which makes the screws invisible. This is a brillant solution and a very good overall improvement in terms of ergonomics.
The back panel is simple and you get seven plus two PCI expansion slots, the opening for the motherboard I/O panel, a 140mm fan slot and the opening for the standard ATX power supply. What's special is the fact that one graphics card can be installed vertically as well, thanks to the two additional expansion slots. Underneath the case there are four plastic feet with an alumium finish and a large opening with a dust filter which ensures that the PSU gets enough fresh air to operate correctly.