The inside of the Define S2 is clean and simple, it again features a rather classic yet highly modular layout. The Define S2 can fit up to three 3.5" HDDs and two 2.5" SSDs. All the drives will find place behind the motherboard tray. Since the placement for the HDD carriages isn't easy to reach, Fractal Design includes SATA power cables in the delivery.
The motherboard tray is made out of solid steel and it features a big opening behind the socket, which allows the user to install an aftermarket CPU cooler without taking the motherboard out. The tray features four openings with rubber grommets to create a neat cable management. Between the motherboard tray and the right panel there is enough space to hide plenty of cables.
For testing purposes we used an MSI Z370 motherboard and a rather chunky AIO cooler from Corsair and we did not run into any compatiblity issues installing the components. Building a PC based on this case is very easy and quickly done no matter whether you're using a CPU tower cooler or an all-in-one liquid cooler, but if you want to enjoy all the benefits of this case you should use a water cooling setup. There is plenty of space for the graphics card so even the most powerful GPUs on the market will fit. The Define S2 is able to accommodate a CPU cooler with a maximum height of 185 mm and graphics cards can measure up to 440mm in length. After having put our test system together the final looks were esthetically pleasing and we like the end result.